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These have a means of ignition to produce the flame, and some provision for extinguishing the flame or else controlling it to such a degree that users may extinguish it with their breath

Acknowledgements We thank Dr Eugenio Marro for Statistical analysis, Ms Anna Calzolai for the revision of the tables and figures and Mr Salvatore Chiari for the review of the translation

Still a hypothesis While high numbers of goblet and club cells, laden with ACE2 receptors, may explain why smokers fall severely ill of COVID-19, the exact relationship between ACE2 and disease prognosis "remains to be demonstrated," Sheltzer and Smith noted